The 5-Second Trick For indazole synthesis
Substitution at R3 having a halogen or alkoxy group (74f–74i) resulted in a slight increase in mobile potency While using the halide analogs (74g–h) showing best the potency during the group. Even further optimization led to the invention of 74i–j, with 74k as by far the most Energetic compound within the collection (pIC50 = 6.seventy seven)